Challenges for Digital Therapeutics‍ as an Upcoming Industry

Mansha Kapoor
-
January 5, 2024

Introduction

In recent years, the world has witnessed an extraordinary convergence of healthcare and technology, driven in part by the urgent demands brought on by the COVID-19 pandemic. This intersection has given rise to a groundbreaking field known as Digital Therapeutics (DTx), reshaping the healthcare landscape as we know it. These evidence-based software programs promise to prevent, manage, or treat various medical disorders and diseases, often focusing on chronic and behavior-modifiable conditions. From diabetes management to addressing insomnia and substance use disorders, DTx represents a paradigm shift in healthcare, pushing the boundaries of what's possible when cutting-edge technology meets the art of healing.

As we embark on a journey to explore the world of DTx, it becomes apparent that this limitless field has its challenges. DTx manufacturers, despite the immense potential of their products, find themselves navigating complex medical challenges marked by hurdles in clinical trials and commercialization. However, in the face of these challenges, innovation thrives, and transformative solutions emerge.

This blog will delve deep into the challenges digital therapeutics face in today's rapidly evolving healthcare ecosystem. From the shifting perceptions of patients, providers, and payers to the profound impact of the pandemic on regulatory dynamics, we will uncover the key factors shaping the future of DTx. Moreover, we will explore how increased smartphone usage and the growing demand for accessible digital health solutions drive this field's growth. Join us as we unravel the complexities and opportunities that lie ahead for digital therapeutics, paving the way for a healthier, more connected future.

Key Parameters of Digital Therapeutics

Digital Therapeutics (DTx) is a distinct domain within the broader landscape of Digital Health, characterized by its focus on evidence-based therapeutic interventions delivered through digital technology. This approach aims to enhance human health and well-being, improve the quality and safety of healthcare services, boost treatment accessibility, streamline healthcare operations, and curtail the overall costs associated with healthcare delivery.

Within DTx, a fundamental distinction exists between two essential components: the "digital active ingredients" and the "digital excipients." The former constitutes the core of DTx, driving the clinical outcomes by delivering specialized software-based interventions tailored to specific medical conditions. These interventions are akin to the active compounds in traditional drugs, but instead, they are digital.

Complementing the digital active ingredients are the "digital excipients." These digital elements are crucial in ensuring patients have an optimal and engaging experience with the therapy. They encompass a wide range of features such as virtual assistants, reminders, gamification elements, and reward systems, all aimed at promoting patient adherence and commitment to therapy over the long term.

Regarding accessibility and usability, Digital Therapeutics can take on various patient-facing digital forms. These include smartphone applications, interactive video games, virtual reality programs, and other engaging platforms. This flexibility empowers patients to choose the format that aligns best with their preferences and requirements.

The development journey of Digital Therapeutics typically follows a structured path, encompassing software development, pilot testing, and full-scale clinical development. This rigorous process is vital to ensuring the efficacy, safety, and usability of DTx solutions.

Crucially, the credibility and acceptance of Digital Therapeutics hinge on robust clinical evidence. Confirmatory randomized controlled clinical trials play an integral role in generating this evidence, supporting regulatory approval, reimbursement eligibility, and authorization for prescription by healthcare providers.

One of the most promising aspects of Digital Therapeutics lies in its potential to revolutionize the management of chronic diseases. These digital interventions offer a novel therapeutic option for patients with chronic conditions and dependencies, potentially improving their quality of life and health outcomes.

However, it's essential to exercise caution in adopting and integrating Digital Therapeutics into healthcare systems. While they hold immense promise, unintended or adverse effects are also possible. Thus, the introduction, implementation, use, and funding of DTx should be subjected to careful evaluation and continuous monitoring to ensure they deliver the expected benefits while maintaining safety and effectiveness standards within the healthcare landscape. And herein lie the challenges of Digital Therapeutics. 

Top Challenges for Digital Therapeutics

1. Non-availability of comparison information between traditional treatment and DTx

The non-availability of comparison information between Digital Therapeutics (DTx) and traditional treatments presents several challenges to adopting and accepting DTx as a viable medical intervention. Let's break down these challenges and analyze them:

2. Lack of Clinical Evidence

Traditional pharmaceuticals and medical interventions have decades or centuries of clinical data and research supporting their efficacy and safety. In contrast, DTx is a relatively new field, and the amount of clinical evidence supporting its use is limited. This lack of historical data makes it difficult for healthcare providers and regulators to assess DTx's comparative effectiveness confidently.

3. Heterogeneity of DTx

Digital Therapeutics encompasses various digital interventions, from mobile apps to virtual reality programs. Each DTx product may target a specific condition or aspect of health. This heterogeneity makes it challenging to compare DTx as a whole to traditional treatments, as the effectiveness of one DTx may vary significantly from another.

4. Regulatory Hurdles

Regulatory agencies such as the U.S. Food and Drug Administration (FDA) typically require rigorous clinical trials to establish the safety and efficacy of new medical treatments. While some DTx have received regulatory clearance, many are still in the process of obtaining this validation. The lack of a standardized regulatory pathway for Digital Therapeutics adds to the challenge of comparing them to traditional treatments.

5. Reimbursement and Adoption

Healthcare systems and insurance providers often base their decisions on reimbursement and coverage on the availability of robust clinical evidence. With precise comparative data, it's easier to convince payers to support DTx as a viable alternative to traditional treatments, which are typically better understood and documented.

6. Patient and Provider Confidence

Patients and healthcare providers tend to have more confidence in treatments with a long history of proven success. The absence of comparative information can create skepticism about the effectiveness of DTx, leading patients and providers to choose traditional treatments they perceive as more reliable.

7. Long-term Outcomes

Many traditional treatments have well-documented long-term outcomes and side effect profiles. In contrast, the long-term effects and safety of DTx are still largely unknown due to the relatively short duration of their existence. This uncertainty can hinder adoption, particularly for chronic conditions where long-term efficacy and safety are crucial.

There is a need for more rigorous clinical research on DTx, standardized evaluation methodologies, and increased collaboration between healthcare providers, researchers, and technology companies. Comparative studies that directly assess the effectiveness of DTx against traditional treatments for specific conditions are essential to building trust in the field and making informed decisions about their integration into healthcare systems. 

 8. Patient’s ability to engage with Technology

Digital Literacy: Not all patients are equally comfortable or proficient using digital devices and software. Older adults, individuals from lower socioeconomic backgrounds, or those with limited exposure to technology may struggle to navigate digital therapeutics. This limited digital literacy can hinder their ability to access and benefit from these tools.

-Access to Technology: Some patients may need the necessary technology, such as smartphones, tablets, or computers, to engage with digital therapeutics. This digital divide can result in unequal access to healthcare interventions and exacerbate health disparities.

-Limited Internet Connectivity: Even if patients have access to digital devices, they may need help with internet connectivity. Slow or unreliable internet connections can disrupt the use of digital therapeutics, making it easier for patients to follow their treatment plans consistently.

-Cognitive Impairments: Patients with cognitive impairments, such as dementia or severe mental health disorders, may find it challenging to engage with technology. They may need help with complex interfaces, memory issues, or difficulties following digital instructions.

-User Experience Design: If digital therapeutics do not have user-friendly interfaces, clear instructions, and intuitive navigation, patients of all ages and backgrounds may need clarification and support. This limitation can lead to reduced engagement and adherence to treatment plans.

-Privacy and Security Concerns: Patients may be concerned about their health data's privacy and security when using digital therapeutics. Worries about data breaches or misuse can discourage some individuals from fully engaging with these tools.

-Motivation and Engagement: Some patients may need more motivation to use digital therapeutics consistently. Unlike face-to-face interactions with healthcare providers, digital tools provide a different level of encouragement or accountability, making it easier for patients to disengage.

-Technical Support and Training: Patients may require technical support and training to use digital therapeutics effectively. Healthcare providers must allocate resources to ensure that patients receive the necessary education and assistance, which can be resource-intensive.

-Language and Cultural Barriers: Language barriers or cultural differences can make engaging with technology-based interventions challenging for some patients. Content may not be available in their preferred language, or the cultural context may not align with their beliefs and practices.

-Resistance to Change: Some patients may prefer traditional healthcare approaches and resist adopting digital solutions. Overcoming resistance to change can be a significant hurdle in promoting the adoption of digital therapeutics.

The ability of patients to engage with technology can be a multifaceted challenge for digital therapeutics. Therefore, it is essential for healthcare providers and developers to consider the diverse needs and limitations of the patient population and to design digital therapeutic solutions that are accessible, user-friendly, and supportive of patient engagement. Additionally, addressing issues related to digital literacy, access, and privacy concerns is crucial to ensure that digital therapeutics can reach and benefit a wide range of patients.

Technical Challenges of Digital Healthcare Systems

1. Data Integration

Integrating digital therapeutics into existing healthcare systems can be complex. Ensuring seamless data flow between the therapy platform and a patient's medical records is critical but technically challenging.

2. Interoperability:

Different healthcare providers may use various software and data formats. Achieving interoperability, where digital therapeutics can work across diverse systems, can be a technical struggle.

3. Security and Privacy:

Protecting patient data is paramount. Providers must implement robust security measures to safeguard sensitive health information from breaches or unauthorized access.

4. User Experience:

A technical challenge is designing user-friendly interfaces and ensuring healthcare professionals can easily access and interpret patient data. A good user experience can help adoption.

5. Scalability:

As the demand for digital therapeutics grows, providers must scale their platforms efficiently to accommodate more patients while maintaining performance and reliability.

6. Regulatory Compliance:

Complying with healthcare regulations and standards, such as HIPAA in the United States, requires technical expertise to ensure that digital therapeutics meet legal requirements.

7. Remote Monitoring:

Enabling real-time remote monitoring of patients involves setting up secure and reliable connections between devices and healthcare providers, which can be technically demanding.

Addressing these technical challenges is crucial to successfully integrating and adopting digital therapeutics in healthcare.

Maintaining an Evolving Service Delivery Infrastructure

Maintaining an evolving service delivery infrastructure is one of the challenges in digital therapeutics. Digital therapeutics (DTx) refers to evidence-based therapeutic interventions delivered through software or digital platforms to prevent, manage, or treat medical conditions. Following is an explanation and expansion on why maintaining such an infrastructure can be challenging:

1. Rapid Technological Advancements:

Technology in the healthcare industry is constantly evolving. New devices, software, and data management tools are invented and upgraded frequently. This continuous evolution means that digital therapeutics providers must stay up-to-date with the latest advancements to ensure their infrastructure remains relevant and effective.

2. Regulatory Compliance:

The healthcare industry is heavily regulated, and digital therapeutics are no exception. Providers must navigate a complex landscape of regulatory requirements, including data privacy (e.g., GDPR or HIPAA) and medical device regulations. Staying compliant with evolving regulations can be a significant challenge.

3. Interoperability:

Digital therapeutics must often integrate with other healthcare systems, such as electronic health records (EHRs), wearable devices, and telehealth platforms. Ensuring seamless interoperability and data exchange between these systems can be complex, especially as different systems evolve independently.

4. Scalability:

Providers must be prepared to scale their infrastructure rapidly as digital therapeutics gain popularity and reach a wider audience. Handling increased user loads and maintaining service quality while scaling up can be a technical challenge.

5. Data Security:

Handling sensitive patient data is critical to digital therapeutics. Maintaining robust data security measures to protect patient information from cyber threats is essential. As cyber threats evolve, so must the security measures in place.

6. User Experience:

The user experience is crucial for the success of digital therapeutics. As user expectations evolve, providers need to continually enhance their platforms' user interface, features, and overall usability.

7. Clinical Validation:

Digital therapeutics must demonstrate their efficacy through clinical trials and real-world evidence. Maintaining a constantly evolving body of evidence and incorporating new findings into the service is challenging.

8. Content Updates:

Content within digital therapeutics, such as educational materials, exercises, or treatment plans, may need to be regularly updated to reflect the latest medical guidelines and research. Ensuring that content remains evidence-based and up-to-date requires ongoing effort.

9. Feedback Integration:

Collecting and incorporating feedback from users and healthcare professionals is essential for improving digital therapeutics. Managing user feedback, prioritizing feature requests, and implementing changes can be demanding.

10. Business Model Adaptation:

Digital therapeutics providers may need to adapt their business models as the healthcare landscape changes. This real-time adaptation includes pricing strategies, reimbursement models, and partnerships with healthcare providers.

Overcoming the discussed challenges requires a commitment to ongoing innovation, a deep understanding of healthcare regulations, and a focus on delivering effective, evidence-based therapeutic interventions.

Pinpointing Service Performance Issues

Pinpointing service performance issues in the context of digital therapeutics can indeed be a daunting task. Digital therapeutics often use software and technology to remotely deliver medical interventions or treatments. Here are several reasons why identifying and resolving performance issues in this domain can be particularly challenging:

1. Complexity of Software:

Digital therapeutics software often involves multiple components such as mobile apps, web interfaces, back-end servers, and data analytics algorithms. Identifying where performance issues originate within this intricate ecosystem can be difficult.

2. Data Sensitivity:

Digital therapeutics often deal with sensitive patient data. Therefore, extensive testing and monitoring must be conducted while adhering to strict privacy and security regulations, which can slow down the troubleshooting process.

3. Real-time Requirements:

Many digital therapeutics require real-time monitoring and feedback, especially those involving continuous patient monitoring or feedback. Even slight performance delays can affect the effectiveness of the therapy.

4. User Experience:

The user experience is crucial in digital therapeutics. Any performance issues that impact usability or cause frustration for patients can be detrimental to the success of the therapy.

5. Device Compatibility:

Digital therapeutics may need to run on various devices and platforms, which can introduce compatibility issues that affect performance. Ensuring that the software works seamlessly across different devices can be challenging.

6. Network Connectivity:

Connectivity issues can disrupt the delivery of digital therapeutics services, particularly for remote monitoring and telehealth applications. Diagnosing whether performance issues are related to the software or network problems can be tricky.

7. Scalability:

Scalability becomes a concern if a digital therapeutic gains popularity and a large user base. Ensuring the service can handle increased traffic and user load without performance degradation can be challenging.

8. Regulatory Compliance:

Digital therapeutics often need to adhere to regulatory requirements, which can impose additional constraints on identifying and resolving performance issues. Changes to the software may require revalidation.

9. Clinical Impact:

Performance issues in digital therapeutics can have direct clinical consequences. If a service fails to deliver therapy or monitoring as expected, patient health may be at risk.

Organizations developing digital therapeutics must implement rigorous testing and monitoring procedures to address these challenges. This dev elopement exercise may involve continuous performance testing, load testing, security testing, and compliance checks. Additionally, real-time monitoring and alerting systems can help detect and address performance issues as they occur.

Collaboration between technical teams, clinical experts, and regulatory bodies is essential to ensure the service meets technical and clinical standards. Therefore, pinpointing service performance issues in digital therapeutics requires a multidisciplinary approach and a deep understanding of the unique challenges posed by this field.

Ensuring 24/7/365 Availability of Clinical Applications:

Ensuring 24/7/365 availability of clinical applications, especially in digital therapeutics, is a significant challenge. Digital therapeutics are software-based interventions designed to prevent, manage, or treat medical conditions. These applications often play a critical role in healthcare delivery, patient management, and data collection, making their continuous availability essential. Here are some reasons why achieving this level of availability can be challenging:

1. High-Reliability Requirements: Clinical applications must be highly reliable because downtime can disrupt patient care and data collection. This disruption means that infrastructure and software must be meticulously designed and tested to minimize the risk of failure.

2. Patient Dependence: Patients may rely on these applications for continuous monitoring, medication reminders, or therapeutic interventions. Any interruption in service can negatively impact patient outcomes and safety.

3. Regulatory Compliance: Many clinical applications must adhere to strict regulatory requirements, such as those from the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA). Compliance often involves demonstrating the ability to maintain continuous availability and data security.

4. Scalability: As the user base grows, the infrastructure and resources must be able to scale to accommodate increased demand. Managing increased demand can be particularly challenging when dealing with unexpected spikes in usage, such as during public health emergencies.

5. Data Security and Privacy: Clinical applications typically handle sensitive patient data, making data security and privacy paramount. Ensuring constant availability while maintaining data integrity and security is a complex task.

6. System Failures: Hardware failures, software bugs, and other technical issues can occur at anytime. Implementing redundancy and failover mechanisms is essential to minimize downtime in such cases.

7. Network Connectivity: Many digital therapeutics rely on an internet connection, and network outages can disrupt service. Ensuring redundant network connections and monitoring network issues are essential for availability management.

8. Maintenance and Updates: Routine maintenance, updates, and patches are necessary for keeping the application secure and up-to-date. These activities must be carefully planned to minimize disruptions.

9. Monitoring and Response: Constant monitoring of the application's health is essential. A robust monitoring system can help identify issues early and trigger rapid response and resolution.

10. Cost: Achieving continuous availability can be expensive. Maintaining redundant servers, data centers, other infrastructure components, and associated personnel and resources can strain budgets.

To address these challenges, organizations developing digital therapeutics need to implement a combination of technical, operational, and organizational strategies, including:

- Redundancy: Deploying redundant servers, data centers, and network connections to minimize the impact of hardware or network failures.

-Load Balancing: Distributing traffic across multiple servers to prevent overload on any single server.

- Disaster Recovery and Business Continuity Planning: Developing plans and procedures for handling unforeseen events and disasters.

- Automated Monitoring and Alerts: Implementing robust monitoring tools to detect issues and notify administrators in real time.

- Regular Testing and Simulation: Conduct routine testing and simulations to ensure that failover and recovery mechanisms work as expected.

- Security Measures: Implementing robust security measures to protect patient data and ensure compliance with regulations.

- Continuous Improvement: Regularly reviewing and improving system performance and availability based on monitoring data and feedback.

Ensuring the 24/7/365 availability of clinical applications in digital therapeutics is challenging due to the high stakes in patient care and data integrity. It requires a holistic approach that combines technical solutions, operational practices, and regulatory compliance measures to minimize downtime and maintain continuous service.

-Lack of expertise: The need for expertise is a significant challenge in digital therapeutics. Digital therapeutics (DTx) is a category of evidence-based therapeutic interventions driven by software programs and technology platforms to prevent, manage, or treat medical conditions. These interventions often leverage elements of behavioral therapy, clinical guidelines, and data analytics to deliver personalized patient care.

Here's why the lack of expertise is a notable challenge in this emerging field:

1. Multidisciplinary Nature:

Digital therapeutics require expertise from various disciplines, including medicine, healthcare, software development, data analytics, user experience design, regulatory affairs, and more. Building effective digital therapeutic solutions requires a coordinated effort among experts from these diverse backgrounds. A lack of expertise in any of these areas can hinder developing and deploying digital therapeutics.

2. Clinical Validation:

Digital therapeutics must undergo rigorous clinical validation to prove their safety and efficacy. Clinical trials and studies are essential to demonstrate that a digital therapeutic can produce meaningful health outcomes. With expertise in clinical research and trial design, developing a robust evidence base for these interventions can be more manageable.

3. Regulatory Compliance:

The healthcare industry is highly regulated, and digital therapeutics are no exception. Regulatory agencies like the U.S. Food and Drug Administration (FDA) have specific requirements for the approval and marketing of digital therapeutics. Ensuring compliance with these regulations demands expertise in regulatory affairs and quality assurance.

4. Data Privacy and Security:

Digital therapeutics often involve collecting and analyzing sensitive patient data. Maintaining the privacy and security of this data is crucial to building trust with patients and complying with data protection laws. Expertise in cybersecurity and data privacy is essential to mitigate risks in this area.

5. User Experience and Engagement:

Digital therapeutics must engage and motivate patients to adhere to their treatment plans. Providing motivation requires expertise in user experience (UX) design and behavioral psychology to create user-friendly and engaging interfaces.

6. Integration with Healthcare Systems:

Digital therapeutics must integrate seamlessly with existing healthcare systems, such as electronic health records (EHRs) and clinical workflows. Expertise in healthcare interoperability and system integration is necessary to ensure smooth implementation.

7. Reimbursement and Market Access:

Getting digital therapeutics reimbursed by healthcare payers is a complex process that requires expertise in health economics, health policy, and market access strategies. With this knowledge, digital therapeutics may gain widespread adoption.

8. Continuous Improvement:

Digital therapeutics should evolve based on patient feedback, new research, and emerging technologies. Expertise in product management and a commitment to continuous improvement are crucial for optimizing these interventions over time.

Lack of expertise in digital therapeutics, including clinical validation, regulatory compliance, data security, user experience design, and more, poses a significant challenge. Developing effective and safe digital therapeutic solutions requires a multidisciplinary approach and a deep understanding of healthcare and technology. Overcoming this challenge involves cultivating a pool of professionals with the necessary skills and knowledge to drive innovation and improve patient outcomes in digital therapeutics.

Conclusion

Digital therapeutics present a groundbreaking shift in modern healthcare, offering personalized, accessible, and cost-effective treatments. However, the path to widespread adoption is littered with challenges. Regulatory hurdles are a significant roadblock, necessitating stringent proof of efficacy and safety to secure approval, a process often lengthy and costly. These technologies also face skepticism from traditional healthcare practitioners and patients accustomed to conventional treatment methods, underscoring the need for substantial, clinically validated evidence and transparent communication about their benefits and limitations.

Furthermore, data security raises critical concerns. With cyber threats on the rise, protecting sensitive health information collected by digital therapeutics platforms is paramount. It necessitates state-of-the-art cybersecurity protocols, which can be resource-intensive for developers. Lastly, issues of scalability and accessibility persist. To bridge the digital divide, companies must consider socio-economic disparities, ensuring these innovations are not just for the privileged but accessible and affordable to all demographics.

Despite these challenges, the potential of digital therapeutics is undeniable. They could revolutionize treatment protocols, improve healthcare quality, and democratize access globally. Success hinges on collaborative efforts between developers, regulators, healthcare providers, and patients, forging a path that upholds safety, trust, and inclusivity.

Mahalo Health stands at the forefront of Digital Therapeutics (DTx) platforms, dedicated to revolutionizing healthcare. Mahalo empowers individuals to manage chronic conditions by delivering personalized, data-driven interventions. Its intuitive interface, data insights, and remote monitoring foster patient engagement, leading to improved treatment outcomes. Mahalo Health is pioneering precision medicine through technology, setting new standards in DTx innovation, and promoting holistic well-being. Contact us for more information.

Experience Mahalo's transformative platform. Book a demo today!

  • United States+1
  • United Kingdom+44
  • Afghanistan (‫افغانستان‬‎)+93
  • Albania (Shqipëri)+355
  • Algeria (‫الجزائر‬‎)+213
  • American Samoa+1
  • Andorra+376
  • Angola+244
  • Anguilla+1
  • Antigua and Barbuda+1
  • Argentina+54
  • Armenia (Հայաստան)+374
  • Aruba+297
  • Ascension Island+247
  • Australia+61
  • Austria (Österreich)+43
  • Azerbaijan (Azərbaycan)+994
  • Bahamas+1
  • Bahrain (‫البحرين‬‎)+973
  • Bangladesh (বাংলাদেশ)+880
  • Barbados+1
  • Belarus (Беларусь)+375
  • Belgium (België)+32
  • Belize+501
  • Benin (Bénin)+229
  • Bermuda+1
  • Bhutan (འབྲུག)+975
  • Bolivia+591
  • Bosnia and Herzegovina (Босна и Херцеговина)+387
  • Botswana+267
  • Brazil (Brasil)+55
  • British Indian Ocean Territory+246
  • British Virgin Islands+1
  • Brunei+673
  • Bulgaria (България)+359
  • Burkina Faso+226
  • Burundi (Uburundi)+257
  • Cambodia (កម្ពុជា)+855
  • Cameroon (Cameroun)+237
  • Canada+1
  • Cape Verde (Kabu Verdi)+238
  • Caribbean Netherlands+599
  • Cayman Islands+1
  • Central African Republic (République centrafricaine)+236
  • Chad (Tchad)+235
  • Chile+56
  • China (中国)+86
  • Christmas Island+61
  • Cocos (Keeling) Islands+61
  • Colombia+57
  • Comoros (‫جزر القمر‬‎)+269
  • Congo (DRC) (Jamhuri ya Kidemokrasia ya Kongo)+243
  • Congo (Republic) (Congo-Brazzaville)+242
  • Cook Islands+682
  • Costa Rica+506
  • Côte d’Ivoire+225
  • Croatia (Hrvatska)+385
  • Cuba+53
  • Curaçao+599
  • Cyprus (Κύπρος)+357
  • Czech Republic (Česká republika)+420
  • Denmark (Danmark)+45
  • Djibouti+253
  • Dominica+1
  • Dominican Republic (República Dominicana)+1
  • Ecuador+593
  • Egypt (‫مصر‬‎)+20
  • El Salvador+503
  • Equatorial Guinea (Guinea Ecuatorial)+240
  • Eritrea+291
  • Estonia (Eesti)+372
  • Eswatini+268
  • Ethiopia+251
  • Falkland Islands (Islas Malvinas)+500
  • Faroe Islands (Føroyar)+298
  • Fiji+679
  • Finland (Suomi)+358
  • France+33
  • French Guiana (Guyane française)+594
  • French Polynesia (Polynésie française)+689
  • Gabon+241
  • Gambia+220
  • Georgia (საქართველო)+995
  • Germany (Deutschland)+49
  • Ghana (Gaana)+233
  • Gibraltar+350
  • Greece (Ελλάδα)+30
  • Greenland (Kalaallit Nunaat)+299
  • Grenada+1
  • Guadeloupe+590
  • Guam+1
  • Guatemala+502
  • Guernsey+44
  • Guinea (Guinée)+224
  • Guinea-Bissau (Guiné Bissau)+245
  • Guyana+592
  • Haiti+509
  • Honduras+504
  • Hong Kong (香港)+852
  • Hungary (Magyarország)+36
  • Iceland (Ísland)+354
  • India (भारत)+91
  • Indonesia+62
  • Iran (‫ایران‬‎)+98
  • Iraq (‫العراق‬‎)+964
  • Ireland+353
  • Isle of Man+44
  • Israel (‫ישראל‬‎)+972
  • Italy (Italia)+39
  • Jamaica+1
  • Japan (日本)+81
  • Jersey+44
  • Jordan (‫الأردن‬‎)+962
  • Kazakhstan (Казахстан)+7
  • Kenya+254
  • Kiribati+686
  • Kosovo+383
  • Kuwait (‫الكويت‬‎)+965
  • Kyrgyzstan (Кыргызстан)+996
  • Laos (ລາວ)+856
  • Latvia (Latvija)+371
  • Lebanon (‫لبنان‬‎)+961
  • Lesotho+266
  • Liberia+231
  • Libya (‫ليبيا‬‎)+218
  • Liechtenstein+423
  • Lithuania (Lietuva)+370
  • Luxembourg+352
  • Macau (澳門)+853
  • Macedonia (FYROM) (Македонија)+389
  • Madagascar (Madagasikara)+261
  • Malawi+265
  • Malaysia+60
  • Maldives+960
  • Mali+223
  • Malta+356
  • Marshall Islands+692
  • Martinique+596
  • Mauritania (‫موريتانيا‬‎)+222
  • Mauritius (Moris)+230
  • Mayotte+262
  • Mexico (México)+52
  • Micronesia+691
  • Moldova (Republica Moldova)+373
  • Monaco+377
  • Mongolia (Монгол)+976
  • Montenegro (Crna Gora)+382
  • Montserrat+1
  • Morocco (‫المغرب‬‎)+212
  • Mozambique (Moçambique)+258
  • Myanmar (Burma) (မြန်မာ)+95
  • Namibia (Namibië)+264
  • Nauru+674
  • Nepal (नेपाल)+977
  • Netherlands (Nederland)+31
  • New Caledonia (Nouvelle-Calédonie)+687
  • New Zealand+64
  • Nicaragua+505
  • Niger (Nijar)+227
  • Nigeria+234
  • Niue+683
  • Norfolk Island+672
  • North Korea (조선 민주주의 인민 공화국)+850
  • Northern Mariana Islands+1
  • Norway (Norge)+47
  • Oman (‫عُمان‬‎)+968
  • Pakistan (‫پاکستان‬‎)+92
  • Palau+680
  • Palestine (‫فلسطين‬‎)+970
  • Panama (Panamá)+507
  • Papua New Guinea+675
  • Paraguay+595
  • Peru (Perú)+51
  • Philippines+63
  • Poland (Polska)+48
  • Portugal+351
  • Puerto Rico+1
  • Qatar (‫قطر‬‎)+974
  • Réunion (La Réunion)+262
  • Romania (România)+40
  • Russia (Россия)+7
  • Rwanda+250
  • Saint Barthélemy+590
  • Saint Helena+290
  • Saint Kitts and Nevis+1
  • Saint Lucia+1
  • Saint Martin (Saint-Martin (partie française))+590
  • Saint Pierre and Miquelon (Saint-Pierre-et-Miquelon)+508
  • Saint Vincent and the Grenadines+1
  • Samoa+685
  • San Marino+378
  • São Tomé and Príncipe (São Tomé e Príncipe)+239
  • Saudi Arabia (‫المملكة العربية السعودية‬‎)+966
  • Senegal (Sénégal)+221
  • Serbia (Србија)+381
  • Seychelles+248
  • Sierra Leone+232
  • Singapore+65
  • Sint Maarten+1
  • Slovakia (Slovensko)+421
  • Slovenia (Slovenija)+386
  • Solomon Islands+677
  • Somalia (Soomaaliya)+252
  • South Africa+27
  • South Korea (대한민국)+82
  • South Sudan (‫جنوب السودان‬‎)+211
  • Spain (España)+34
  • Sri Lanka (ශ්‍රී ලංකාව)+94
  • Sudan (‫السودان‬‎)+249
  • Suriname+597
  • Svalbard and Jan Mayen+47
  • Sweden (Sverige)+46
  • Switzerland (Schweiz)+41
  • Syria (‫سوريا‬‎)+963
  • Taiwan (台灣)+886
  • Tajikistan+992
  • Tanzania+255
  • Thailand (ไทย)+66
  • Timor-Leste+670
  • Togo+228
  • Tokelau+690
  • Tonga+676
  • Trinidad and Tobago+1
  • Tunisia (‫تونس‬‎)+216
  • Turkey (Türkiye)+90
  • Turkmenistan+993
  • Turks and Caicos Islands+1
  • Tuvalu+688
  • U.S. Virgin Islands+1
  • Uganda+256
  • Ukraine (Україна)+380
  • United Arab Emirates (‫الإمارات العربية المتحدة‬‎)+971
  • United Kingdom+44
  • United States+1
  • Uruguay+598
  • Uzbekistan (Oʻzbekiston)+998
  • Vanuatu+678
  • Vatican City (Città del Vaticano)+39
  • Venezuela+58
  • Vietnam (Việt Nam)+84
  • Wallis and Futuna (Wallis-et-Futuna)+681
  • Western Sahara (‫الصحراء الغربية‬‎)+212
  • Yemen (‫اليمن‬‎)+967
  • Zambia+260
  • Zimbabwe+263
  • Åland Islands+358
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
©2024  Mahalo Digital Ventures, Inc.